The effect of solifenacin on cognitive function in stroke patients

Abstract

but data are lacking on African Americans (AA). This pilot study will 1) determine whether AA with mild AD can be enrolled, randomized, retained and comply with a 6-month aerobic exercise-training; 2) evaluate the effects of aerobic-fitness on neurocognition using ADAS-Cog as the primary outcome measure; 3) secondarily compare changes in regional cerebral glucose utilization between exerciser and control groups; 4) explore the effects of APOE gene polymorphism on standardized aerobic exercise training-induced changes in neurocognition and on biomarkers; and 5) generate data needed to investigate mechanisms by which aerobic-fitness influence neurocognitive processes. Methods: After obtaining informed consent, participants are screened using pre-specified inclusion exclusion criteria, and a qualifying treadmill test to determine ability to exercise safely; followed by dietary stabilization. After randomizing volunteers into exercise intervention (n1⁄437) and control (n1⁄437) groups, baseline neuropsychological, brain imaging, and biomarker evaluations are performed. Following baseline VO2Max test, the intervention group undergoes supervised aerobic exercise-training 3-times/week, while the control group undergoes stretch-exercise 3-times/week. At the completion of 6-month exercise training, all baseline tests are repeated in both the intervention and control groups. Between groups analysis of the differences in neuropsychological, neuroimaging and biomarker outcomes are performed using appropriate multivariate methods.Results: Preliminarily, results from the first cohort baseline data will be presented. Conclusions: This study will form the basis for large scale clinicaltrials needed to establish the efficacy of the prescription of aerobic fitnesstraining for the prevention or attenuation of Alzheimer’s disease.