Abstract
The effect of fluoride intake in rats as sodium fluoride (NaF) and sodium monofluorophosphate (Na2PO3F) on immobilization of the tibial bone was investigated. After 4 weeks of immobilization intact humeri and non-immobilized and immobilized tibiae were examined for bone thickness, specific gravity, citrate, ash, and calcium, phosphorus and fluoride contents. The results confirm previous findings that administration of fluoride increases the mineralization rate of bones and counteracts the decrease in bone thickness,ash content and specific gravity induced by immobilization, without changing the Ca/P ratio of the ash. The increase in bone thickness was more marked in the Na2PO3F treated rats, in spite of a lower fluoride incorporation. The citrate content was lower in the bones of the NaF-treated rats than in the Na2PO3F-treated and fluoride-free rats.
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