THE EFFECT OF SODIUM ALENDRONATE GEL ON OSSEOINTEGRATION OF SUBMERGED DENTAL IMPLANTS

Abstract

INTRODUCTION: A plenty of materials have been used to increase the success rate, decrease time needed for osseointegration, stimulate bone formation around dental implants. Bisphosphonates increase bone mineral density by inhibiting osteoclast-mediated bone resorption. Alendronate sodium hydrate is a bisphosphonate that potently inhibits bone resorption and is used to treat osteoporosis. A 1% sodium alendronate gel is manufactured and tested in order to accelerate osseointegration around dental implants.OBJECTIVES: This study aims to compare clinically and radiographically the osseointegration for 2 groups of submerged dental implants both in upper anterior and premolar region, first group with the use of local sodium alendronate gel prior to placement of dental implant and the second group without.MATERIALS AND METHODS: A clinical trial on 24 implants divided into 2 groups indicated for dental implant placement in the upper anterior and premolar region selected from the outpatient clinic of the Oral and Maxillofacial department, Faculty of Dentistry, Alexandria University. For the test group 12 implants were placed with sodium alendronate gel just prior to implant placement. For control group 12 implants were placed without sodium alendronate gel.RESULTS: On the 12 week the resonance frequency analysis (RFA) median records were (55.50, 54.0) and the Mean ± SD (55.08 ± 4.94, 54.67 ± 5.69) for the control group and test group, respectively. The bisphosphonate-coated implants showed an increase in implant stability from 0 to 12 weeks more than the control's measures. On the 12 week, the mean peri-implant bone density value was 1417.92 ± 310.54 for control group and 1550.25 ± 286.15 for test group. These increases in the bone density were higher in test group than the control group.CONCLUSIONS: Using sodium alendronate gel with delayed implant placement could enhance the osseointegration around dental implants.