Abstract
The effect of sulphur dioxide on the clearance of Listeria monocytogenes from normal and emphysematous hamsters was assessed by measuring the number of colony forming units recovered from whole lung homogenates. Continuous exposure to SO2 after intratracheal instillation of Listeria significantly altered the clearance of viable bacteria from the lungs of emphysematous but not normal hamsters. Preexposure of hamsters to SO2 for 2 weeks prior to respiratory infection had similar effects. The emphysematous hamsters exposed to SO2 had a lower average number of Listeria in the lungs after the first week of infection than control groups. This effect appears to result from the combined influence of the SO2, the Listeria infection, and the emphysematous condition within the lungs.
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