Abstract
Background and Aim: Anabolic steroids cause damage to various tissues, including the heart. This study aimed to evaluate the effect of aerobic exercise on Malondialdehyde (MDA) and superoxide dismutase (SOD) of heart tissues in rats poisoned with the anabolic steroid Dianabol. Materials and Methods: In this experimental-fundamental study, 18 rats were selected and divided into three 6-series groups, including normal saline intake (Sh), Dianabol (D), and steroid intake with aerobic exercises (D+RT). For six weeks, the steroid and aerobic exercise groups received 5 mg/kg of Dianabol per day peritoneally, and the steroid aerobic exercise group performed aerobic exercise five sessions per week. Measurement of MDA and SOD gene expression in heart tissue was measured by ELISA. Kolmogorov-Smirnov statistical tests, a 1-way analysis of variance with Tukey post hoc test were used to analyze the results (P≤0.05). Results: Steroid Dianabol had a significant effect on increasing MDA (P=0.001) and decreasing SOD (P=0.001) in heart tissue. However, aerobic exercise decreased MDA (P=0.001) and increased the SOD antioxidant index (P=0.000) in the heart tissue of rats exposed to Dianabol. Conclusion: Anabolic steroids appear to increase oxidative stress indices and decrease antioxidants in heart tissue, while aerobic exercise can improve elevated levels of oxidative stress and decreased levels of antioxidants.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
