Abstract
The purpose of this study was to investigate the effect of silicon (Si) supplementation on bone mineral density (BMD) and bone metabolism parameters relative to Ca intake levels in ovariectomized rats. A total of 72 female Wistar rats (six weeks) were ovariectomized (OVX) and divided into six groups, and Si (500 mg of Si per kg of feed) was or was not administered with diets containing various levels of Ca (0.1%, 0.5%, 1.5%) for ten weeks. Si supplementation significantly increased the BMD of the femur and tibia in Ca‐deficient OVX rats, while no change was observed with Si supplementation in the BMD of the spine, femur and tibia in the adequate and high Ca groups. Serum ALP and osteocalcin levels were not affected by Si supplementation or Ca intake levels. CTX levels were significantly decreased as a result of Si supplementation in Ca‐deficient OVX rats. In summary, Si supplementation produced positive effects on bone mineral density in Ca‐deficient OVX rats by reducing bone resorption. Therefore, Si supplementation may also prove to be helpful in preventing osteoporosis in postmenopausal women whose calcium intake is insufficient. <'This work was supported by the Korea Research Foundation Grant funded by the Korean Government (KRF‐2006‐331‐C00315)'>
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