The Effect of Shoulder Muscle Succinylcholine Injection on Foreleg Raising Power (Sion`s Local Paralysis): A second experiment

Abstract

Background\n Sion\'s local paralysis (SLP) is the local application of neuromuscular blocking agents (NMBAs) to achieve local paralytic effects while avoiding the side effects of systemic paralysis.\n\nObjective:\nWe examined the changes in foreleg raising power after Sion\'s local paralysis (SLP) in an advanced porcine model.\n\nMethods:\nThis was a randomized, double blind, placebo-controlled, porcine study. Ten male Korean native Jeju black pigs were randomized into an intervention group (n = 5) and a control group (n = 5). The injection points were in the middle of the left trapezius muscle and middle of the left deltoid muscle, as described in a previous study. The control group received 2 ml normal saline (NS), with 1 ml injected at each point. The intervention group received 0.5 mg/kg succinylcholine diluted to 2 ml in NS, and 1 ml was injected at each point. The height of the left foreleg from the baseline (experimental table) was measured. We measured foreleg height and oxygen saturation at −4, −2, 0, +2, +4, +6, +8, +10, +20, +30, and +60 min. Unlike previous experiments, the study animals received pain stimuli before each measurement using the Kelly forcep that were clamped on their dew claws.\n\nResults:\nAfter SLP, foreleg height values immediately declined in the intervention group by approximately 20%. This effect was sustained for a few minutes. After satisfying the sphericity assumption (P-value = 0.015), repeated-measures analysis of variance (ANOVA) identified a significant main effect of group (P-value = 0.039) and time (P-value = 0.001) at 0, 2, 4, and 6 min. Hypoxic events were not observed.\n\nConclusions\nCompared with the control group, the foreleg raising power in the intervention group decreased significantly after SLP, without hypoxia, in an advanced pig model.