Abstract
Sevoflurane postconditioning is a potential clinical measure to protect myocardial. This experiment was designed to investigate the efficacy of sevoflurane postconditioning against ischemia-reperfusion injury. A total of 132 Japanese White Rabbits were enrolled into this study. They were underwent 15-, 30-, or 60-min left anterior descending coronary (LAD) artery occlusion, respectively. At the end of LAD artery occlusion, they randomly received a 5-min inhalation of air (control group), 1% sevoflurane (1% sev group), 2% sevoflurane (2% sev group), 4% sevoflurane (4% sev group) or an IV bolus injection of 5mg/kg of NIM811 [a specific inhibitor of mitochondrial permeability transition pores (mPTP)]. Infarct size was determined after 2h of reperfusion (triphenyltetrazolium chloride straining, percentage of risk area). The infarct sizes were significantly (P<0.05) reduced after 15min ischemia (5.5±3.3%, 5.8±3.6% vs. 20.3±6.9% for 2% sev, 4% sev vs. control, respectively) and 30min ischemia (23.5±5.0%, 20.7±5.9% vs. 50.9±10.2%, for 2% sev, 4% sev vs. control, respectively; P<0.05). However, it had no effect on infarct size after 60min ischemia (64.1±5.9%, 62.3±7.6% vs. 72.7±9.2% for 2% sev, 4% sev vs. control, respectively, P>0.05).The efficacy of sevoflurane postconditioning gradually weakened with increasing ischemia duration and disappears after 60min ischemia in rabbits in vivo.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
