Abstract
Objective: To understand the effects of several commonly used antipsychotics on the renal function of patients with mental illness. Method: Collected patients with mental illness who were hospitalized in our hospital from January 2020 to June 2021, and selected as the research subjects patients with psychiatric disorders who were treated with 2 kinds of commonly used antipsychotic drugs; and collected 3 ml of venous blood before treatment and one month after treatment for renal function tests; observed the changes of renal function indexes before and after treatment. Results: In the collected 694 patients with mental illness, before using antipsychotic drugs, the renal function indexes were BUN: 4.42 ± 1.92 mmol/l; Cr: 70.97 ± 16.92 μmol/l; CCr: 88.37 ± 21.07 ml/min; β2-MG: 1.67 ± 0.61 mg/L; UA: 359.90 ± 112.82 μmol/l; CYS-C: 0.92 ± 0.24 mg/L. One month after using antipsychotics, BUN: 3.77 ± 1.37 mmol/l; Cr: 70.46 ± 16.71 μmol/l; CCr: 87.78 ± 20.63 ml/min; β2-MG: 1.75 ± 0.64 mg/L; UA: 332.53 ± 91.48 umol/l; CYS-C: 0.92 ± 0.24 mg/L; the renal function indexes of urea nitrogen, β2 microglobulin, uric acid and other items all changed significantly. The differences before and after treatment were statistically significant, P < 0.01. Conclusion: Several commonly used antipsychotic drugs have a greater impact on the renal function of patients with mental illness. During the treatment, the changes in renal function should be monitored regularly, if severe renal damage is found, the treatment plan or dosage should be adjusted in time to avoid endangering life.
Highlights
Used antipsychotic drugs mainly include clozapine, aripiprazole, risperidone, perphenazine, chlorpromazine, sulpiride, etc
Risperidone is a drug mainly used to treat patients with acute or chronic schizophrenia, especially for the presence or absence of obvious symptoms and complicated affective mental illnesses such as anxiety and depression; it can reduce the emotional symptoms associated with schizophrenia; risperidone has a good effect on patients in the acute phase, and can still play a good clinical effect during the later maintenance treatment
Perphenazine is mainly used for the treatment of symptomatic mental illness, reactive psychosis and paranoid psychosis; it has certain effects on simple and chronic schizophrenia; it has a certain therapeutic effect on nausea, vomiting, hiccups, etc.; those with symptoms of anxiety or nervousness can use this drug in combination with other drugs for treatment
Summary
Used antipsychotic drugs mainly include clozapine, aripiprazole, risperidone, perphenazine, chlorpromazine, sulpiride, etc. These drugs have certain effects on the treatment of patients with mental illness [1-3]. Sulpiride is a drug that has a good effect on withdrawal, depression, apathy, hallucinations, stupor, and delusions; it has a good effect on various types of symptoms of schizophrenia; it has a certain therapeutic effect on depression [4-6]. These drugs have different effects on mental illness, they have certain side effects, especially kidney damage. In order to explore the renal damage caused by several commonly used antipsychotic drugs, the subjects were followed up and observed in this study, and the results are reported as follows
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