The effect of sesame intake on adult albino rat testis during sildenafil long-term administration

M Goweder Fawzia,A A El-Sayed,T M Abu El-Nasr

doi:10.1186/s41936-020-00202-x

M Goweder Fawzia, A A El-Sayed + Show 1 more

Open Access

https://doi.org/10.1186/s41936-020-00202-x

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Abstract

BackgroundSildenafil (Viagra) is widely used for the treatment of erectile dysfunction under various etiologies. Unfortunately, chronic administration of sildenafil negatively affects fertility. The aim of the present study is to investigate the improvement role of sesame on the testis alterations caused by long-term administration of sildenafil on albino rats.ResultsLight microscopically observations showed that overdoses of sildenafil had provoked tubular and interstitial histological alterations. Tubular degeneration and abnormality in the germinal epithelium of the seminiferous tubules included spermatocyte degeneration and arrest of spermatogenesis. Sperm count and motility were negatively affected by sildenafil. These alterations were improved by sesame feeding.ConclusionSesame intake improve the side effects of prolonged treatment with sildenafil significantly. These results demonstrate the pivotal role of sesame that may improve male infertility.

Highlights

Sildenafil (Viagra) is widely used for the treatment of erectile dysfunction under various etiologies
Effect of sildenafil citrate on sperm count and motility Long-term administration of sildenafil (0.3 and 0.6 mg) in male rats caused a significant reduction in the number of sperms comparing with control group (Table 1)
Supplementation of the normal rats diet with sesame significantly improve the total sperm count as well as motility as in group II (Table 2)

Summary

Introduction

Sildenafil (Viagra) is widely used for the treatment of erectile dysfunction under various etiologies. The aim of the present study is to investigate the improvement role of sesame on the testis alterations caused by long-term administration of sildenafil on albino rats. From the chemical composition of sesame, it is known that the seeds contain 50–60% oil, 18–25%, protein, 13.5% carbohydrate, and 5% ash (Elleuch, Besbes, Roiseux, Blecker, & Attia, 2007). They are good sources of vitamin B like niacin, thiamine, folic acid, pyridoxine, and riboflavin. Due to the paucity of knowledge, the present study is designed to evaluate the effect of a diet which contains sesame on some sperm parameters and testicular alterations of male rats after long-term administration of Viagra

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