Abstract
The Effect of Serum Carrying Total Flavonoids of Rhizoma Drynariae on the Proliferation and Apoptosis of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
Highlights
Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease
It is generally believed that the dysfunction caused by RA, cartilage damage, and bone invasion are closely related to the lack of apoptosis of fibroblast-like synoviocytes (FLSs), and insufficient apoptosis is an important cause of most tumors and autoimmune diseases [1]
Effect of Drug-Carrying Serum on the Expression of Proliferating Cell Nuclear Antigen (PCNA) mRNA and Bcl-2 mRNA in FLSs in vitro a) The third-generation osteoblasts were digested with 0.25% trypsin to prepare a single cell suspension by repeated pipetting; the cell concentration was adjusted to 2×10 4/mL, and the cells were seeded onto a 12-well cell culture plate in 1mL per well
Summary
Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease. It is generally believed that the dysfunction caused by RA, cartilage damage, and bone invasion are closely related to the lack of apoptosis of fibroblast-like synoviocytes (FLSs), and insufficient apoptosis is an important cause of most tumors and autoimmune diseases [1]. Inhibition of the apoptosis of FLSs can effectively treat RA [2]. Drynaria is named as monkey ginger or turmeric. Previous studies have shown that total flavonoids of Rhizoma Drynariae have anti inflammatory and osteogenesis effects [3]. The effect of total flavonoids of Rhizoma Drynariae on the treatment of RA is rarely reported. The effect of total flavonoids of Rhizoma Drynariae on RA was observed
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