The effect of separate and combined action of lead oxide and gamma radiation on immunological reactivity and biochemical processes in the organs of immunogenesis

Abstract

Background: The problem of the effects of ionizing radiation on the human body in the conditions of professional activity has attracted increased interest in recent years. This article is devoted to the study of the results of the influence of negative environmental factors on a living organism in real conditions, which is almost always combined. Objective: to evaluate the effect of separate and combined exposure to low doses of ionizing gamma radiation and oral intake of lead (IV) oxide into the body on the activity of oxidative, antioxidant mechanisms and cellular immunity in the experiment.Materials and methods: Studies were conducted on 120 white mongrel sexually mature rats: 4 groups of equal numbers, males weighing 180-270 g. The state of lipid peroxidation and antioxidant protection was assessed in the tissues of the thymus and spleen. The state of antioxidant protection was assessed by the activity of catalase, glutathione reductase and glutathione peroxidase in the same tissues. Indicators characterizing the cellular link of immunity were determined in all experimental animals.