The effect of selenium and multiple micronutrient administration during periconception period on the level of malondialdehyde

Abstract

This study aimed to prove the effect of Selenium during periconception to the level of Malodialdehyde in pregnancy. This study was double blind, randomised, control community based trial design. The intervention group (10 periconception women) received Selenium in Multimicronutrient (MMN), while the control group (22 periconception women) given capsules containing Iron and Folic Acid. During preconceptional period, the capsules was given once a week, while in pregnant women was once a day. At the 12th and 20th weeks of pregnancy, selenium and MDA were measured. Statistical analysis using independent T-test, Paired T-Test and PLS analysis. At the 12th weeks of pregnancy the level of MDA in Multimicronutrient group was 121.2ng/mL and IFA group was 1436ng/mL, and at the 20th weeks in MMN group was 108.4ng/Ml and IFA group was 199.6ng/mL. There was a no significant difference between MDA in two groups (p=0.424) at 12th week, but at 20th weeks MMN group had a significantly lower MDA levels (p=0.006) than IFA group. The administration of selenium in MMN preparations since the preconception period has a better effect in reducing MDA levels compared to the IFA group.