Abstract
This study examined the effect of selenium (Se) or lycopene (Lyc) and their combination on oxida- tive stress in bone following cadmium (Cd) exposure in vivo. Cd exposure enhanced accumulation of Cd in femur with subsequent increase in LPO and PC and decreased antioxidative enzyme activ- ities in rat femur, along with significant decreases in body and femur bone weights. Subcutaneous (s.c.) injection of Se or Lyc reduced Cd accumulation in bone and increased body and femur weights, when given individually or concomitantly. Antioxidant enzyme activities maintained and/or in- creased following Se and Lyc supplementation when given individually or concomitantly. However, lycopene dose of 10 mg/kg of body weight alone or selenium alone provided better protection to bone tissues of rats against oxidative stress compared to treatment with their combination. Sele- nium and lycopene could be used as a dietary supplement to protect against bone oxidative stress in areas exposed to Cd pollution.
Highlights
Industrial development in Saudi Arabia has led to various environmental pollutions especially with heavy metals
Data are lacking in the literature on the effects of selenium and lycopene on cadmium concentration on bone tissue and this study report such data for the first time
Lipid peroxidation was increased significantly (P ≤ 0.05) by 79% in rats exposed to cadmium compared to rats in the control group; both selenium and lycopene either alone or in combination prevented the effect of cadmium and the lipid peroxidation level in the treated rats maintained to its normal level as in the control group (Table 5)
Summary
Industrial development in Saudi Arabia has led to various environmental pollutions especially with heavy metals. (2014) The Effect of Selenium and Lycopene on Oxidative Stress in Bone Tissue in Rats Exposed to Cadmium. Pollution of rice consumed in Saudi Arabia has increased due to contamination by cadmium [2]. Study conducted by Al-Farraj and Al-Wabel [3] confirmed the increase in cadmium contamination in soils of Saudi Arabia. They pointed out that contamination of soil with cadmium in Mahd Alzahab (South East of the city of Madinah, Saudi Arabia) comprised 88% of the total heavy metals contamination. The aim of this research was to evaluate the effect of selenium and lycopene alone or in combination on oxidative stress in bone tissue in rats exposed to cadmium
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