Abstract
The effect of physiological dose of purified secretin on glucose-stimulated insulin secretion was studied in healthy volunteers during a continuous infusion of glucose. The intravenous injection of ten unit of secretin during the infusion of glucose caused a greater rise in plasma insulin level and a more marked decrease in blood glucose concentration than either the infusion of glucose or secretin alone did, resulting in a significant increase in the insulinogenic index. One unit of secretin has no effect on plasma insulin and glucose concentrations in the fasting or hyperglycemic state.The physiological role of secretin in regulating insulin secretion after ingestion of food was discussed.
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