Abstract
Safflower yellow (SY) is the safflower extract and is the one of traditional Chinese medicine. The aim of the present work was to investigate the effect of SY on spinal cord ischemia reperfusion injury (SCIRI) in rabbits. The models of spinal cord ischemia reperfusion (SI/R) were constructed, and the degree of the post-ischemic injury was assessed by means of the neurological deficit scores and plasma levels of lipid peroxidation reactioin and neuronal morphologic changes. SCIRI remarkably affected the functional activities of the hind limbs and activated lipid peroxidation reaction. SY could attenuate apoptosis and SCIRI by enhancing Bcl-2 expression and inhibiting Bax and caspase-3 activation.
Highlights
According to the pathophysiologic features, spinal cord injury is mainly categorized into primary injury and secondary injury
Spinal cord ischemia reperfusion injury (SCIRI) is defined as follows: after removing the factors that cause spinal cord ischemia and the recovery of spinal cord blood supply, its neuronal function cannot be improved and its ischemia injury is more intense than its original level, or even present in the irreversible tardive dead phenomenon on spinal cord neurons [3]
Twenty-four rabbits were randomly divided into three groups (n = 6 per group): shamoperated control (Cont), spinal cord ischemia reperfusion (SI/R), and SI/R treated with safflower yellow (SI/R + Safflower yellow (SY))
Summary
According to the pathophysiologic features, spinal cord injury is mainly categorized into primary injury and secondary injury. SCIRI is one of the most frequent types of secondary spinal cord injury and it aggravates the neuro functional impairment of the limbs. Our previous study indicated that SY alleviated the injured tendon adhesion and inflammatory reaction and promoted the repair of injured tendon [2]. It is still unknown whether SY can effectively protect against SCIRI.
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