The effect of rutin on lipid profile and liver function enzymes on alloxan induced hyperglycaemic wistar rats

Abstract

The aim of this research was to investigate the effects of rutin on lipid profile and liver function enzymes on alloxan induced hyperglycaemia in Wistar rats. Hyperglycaemic was induced by intraperitoneal injection of 150 mg/kg alloxan monohydrate. The rats were grouped into five groups of five rats each. Group 1 served as the diabetic negative control, Group 2 served as positive control and was treated with 2 mg/kg glibenclamide, while Groups 3, 4 and 5 were treated with 50, 100 and 200 mg/kg body weight of rutin respectively. Rutin was administered to the animals orally for a period of four weeks. At the end of the experimental period, the rats from each experimental group were sacrificed using light chloroform and sera were collected for the determination of lipid profile and liver function enzymes. There was a significant ( p <0.05) decreased in the total cholesterol, triglyceride and low density lipoprotein as compared to control. However, there was a significant ( p <0.05) increased in the level of high density lipoprotein when compared to diabetic control. Furthermore, there was a significant ( p <0.05) decreased in the serum liver enzymes; Aspartate transaminase (AST) Alanine transaminase (ALT) and Alkaline phosphates (ALP) as compared to control. As regards to the reference drug 2mg/kg glibenclamide there was a significant ( p <0.05) increased in the liver enzymes function as compared to control. Conclusion, rutin has hypolipidemic effect and also decreased liver function enzymes activity on alloxan induced hyperglycaemic rats . Keywords: Rutin, Hyperglycaemia, Alloxan, Lipid profile, Liver enzymes