Abstract
Objective: To determine whether routine magnesium supplementation has beneficial effects on blood lipids and blood pressure in cyclosporine-treated stable renal allograft recipients. Design: Randomized, double-blind, cross-over trial. Setting: University-affiliated medical center. Patients: Twenty-six cyclosporine-treated renal transplant patients with a serum creatinine level less than 220 μmol/L (2.5 mg/dL). Intervention: Oral magnesium hydroxide (approximately 20 to 30 mmol/d [40 to 60 mEq/d]) or placebo. Main outcome measure: Blood pressure and serum lipids. Results: Magnesium supplementation resulted in an increase in serum magnesium (0.74 ± 0.02 mmol/L [1.5 ± 0.1 mEq/L] to 0.81 ± 0.02 mmol/L [1.6 ± 0.1 mEq/L]; P P P P Conclusion: Routine, short-term magnesium supplementation in stable, well-functioning renal transplant recipients has favorable effects on blood lipids.
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