The Effect of Resveratrol on the Composition and State of Lipids and the Activity of Phospholipase A2 During the Excitation and Regeneration of Somatic Nerves.

Victor Vasilevich Revin,Georgiy Vladimirovich Maksimov,Sergey Ivanovich Pinyaev,Marina Vladimirovna Parchaykina,Elvira Sergeevna Revina,Tatyana Pavlovna Kuzmenko

doi:10.3389/fphys.2019.00384

Victor Vasilevich Revin, Georgiy Vladimirovich Maksimov + Show 4 more

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https://doi.org/10.3389/fphys.2019.00384

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Abstract

It has been shown that in the somatic nerve’s lipids, both during excitation and transection, changes occur with the composition of individual phospholipids and in phospholipids fatty acids, which changes the phase state of the myelin and nerve fiber axolemma lipid bilayer. A main contribution in the nerve degenerative processes is dependent on the composition phospholipid’s fatty acid changes during the activation of both Ca2+-dependent and Ca2+-independent phospholipase A2 forms. At the same time, we studded changes in phosphoinisitol (PI) and diacylglycerol (DAG), which depend on the phosphoinositide cycle function during nerve excitation and degeneration processes. It was found that myelin lipids and nerve fiber axolemmas are involved not only in the functioning of the peripheral nerves, but also the pathological processes underlying deep functional and structural disorders. The effect of resveratrol on regeneration processes in the damaged rat sciatic nerve has also been investigated.

Highlights

IntroductionA significant number of studies have shown that the lipid bilayer defines and, in some cases, plays a major role in the functioning of receptors, ion-transporting systems, and most the structures localized in the membrane (Revin et al, 1996, 2006, 2012; Fernandis and Wenk, 2007; Ayala et al, 2014; Ge and Liu, 2016; Pöyry and Vattulainen, 2016).Considering the fact that the bilayer is in different phase states and depends on the composition of individual polar regions in charge-carrying phospholipids and fatty acids forming their hydrophobic areas, it can be assumed that by studying their composition and condition, their participation in the processes of physiological functioning and the primary mechanisms of development of pathological processes can be evaluated (Revin et al, 2006, 2012; Ge and Liu, 2016; Pöyry and Vattulainen, 2016).There is a interest in the study of their role for neurobiology in direction of the excitation conduction of and the damaged somatic nerves regeneration.Excitation and Regeneration of Somatic NervesOne of the classic models for the above processes studes is somatic nerves
It has been known that lipids participate in the functions of cell membranes that are related to their composition and high exchange rate, and various fatty acids determines the bilayer physical state and the ability to oxidize (Revin et al, 2006)
We investigated the change in lipid composition of the rat nerve after stimulation, damage, and resveratrol action

Summary

Introduction

A significant number of studies have shown that the lipid bilayer defines and, in some cases, plays a major role in the functioning of receptors, ion-transporting systems, and most the structures localized in the membrane (Revin et al, 1996, 2006, 2012; Fernandis and Wenk, 2007; Ayala et al, 2014; Ge and Liu, 2016; Pöyry and Vattulainen, 2016).Considering the fact that the bilayer is in different phase states and depends on the composition of individual polar regions in charge-carrying phospholipids and fatty acids forming their hydrophobic areas, it can be assumed that by studying their composition and condition, their participation in the processes of physiological functioning and the primary mechanisms of development of pathological processes can be evaluated (Revin et al, 2006, 2012; Ge and Liu, 2016; Pöyry and Vattulainen, 2016).There is a interest in the study of their role for neurobiology in direction of the excitation conduction of and the damaged somatic nerves regeneration.Excitation and Regeneration of Somatic NervesOne of the classic models for the above processes studes is somatic nerves. A significant number of studies have shown that the lipid bilayer defines and, in some cases, plays a major role in the functioning of receptors, ion-transporting systems, and most the structures localized in the membrane (Revin et al, 1996, 2006, 2012; Fernandis and Wenk, 2007; Ayala et al, 2014; Ge and Liu, 2016; Pöyry and Vattulainen, 2016). There is a interest in the study of their role for neurobiology in direction of the excitation conduction of and the damaged somatic nerves regeneration. The aim of our study was to investigate the composition and condition of lipids changes during the somatic nerves excitation and damage. The enzyme phospholipase A2, especially Ca2+-dependent phospholipase A2, plays an important role in the study of lipid composition (O’Donoghue et al, 2011; Nardicchi et al, 2014)

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