Abstract
Epidural fibrosis (EF) is a common complication for the patients who underwent laminectomy. Recently, EF is thought to cause recurrent postoperative pain after laminectomy. Resveratrol has been shown to exert its anti-inflammatory, antifibrotic, and antiproliferative multifaceted properties. The object of this study was to investigate the effects of resveratrol on the prevention of postlaminectomy EF formation in laminectomy rats. A controlled double-blinded study was performed on 60 healthy adult Sprague-Dawley rats that underwent lumbar laminectomy at the L1-L2 levels. They were divided randomly into 3 groups (1, 2, and 3) of 20 rats each—group 1: resveratrol treatment group; group 2: resveratrol dilution saline treatment group; group 3: sham group (rats underwent laminectomy without treatment). All rats were killed 4 weeks after operation. The Rydell score, hydroxyproline content, vimentin cells density, fibroblasts density, and inflammatory factors expressional levels all suggested better results in resveratrol group than the other two groups. Resveratrol is able to inhibit fibroblasts proliferation, and TGF-β1 and IL-6 expressions and prevent epidural fibrosis in postlaminectomy rat.
Highlights
Over one million patients all over the world undergo lumbar laminectomy for treating disc herniation, making it one of the most widely accepted treatments for lumbosacral disorders [1, 2]
With the characteristics that patients could suffer from the recurrence of continued pain in the lower posterior trunk and/or lower extremities after lumbar laminectomy, failed back surgery syndrome (FBSS) could lead to the failure of the operation [3]
In our laminectomy rat model, we investigated whether resveratrol attenuates Epidural fibrosis (EF) by regulating the expressions of inflammatory factors, such as interleukin 6 (IL6), transforming growth factor-β1 (TGF-β1), and hydroxyproline, which are suggested to be involved in the promotion of EF
Summary
Over one million patients all over the world undergo lumbar laminectomy for treating disc herniation, making it one of the most widely accepted treatments for lumbosacral disorders [1, 2]. Failed back surgery syndrome (FBSS) was reported. With the characteristics that patients could suffer from the recurrence of continued pain in the lower posterior trunk and/or lower extremities after lumbar laminectomy, FBSS could lead to the failure of the operation [3]. As early as in 1948, EF was first mentioned to be a scar tissue adjacent to the dura mater following lumbar laminectomy [4]. Some of them have achieved a certain level of success in animals, there is still no optimal solution which has gained success in clinical application or wide acceptance
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