The Effect of Resistance Training on P53 Gene Expression in Prostate Cancer Patients

Abstract

Background and Objective: Prostate cancer is one of the most common cancers in men, which causes many deaths every year. P53 suppressor protein is one of the indicators the high level of which in the serum of cancer people is related to a decrease in the growth rate of cancer cells that prevents the development of cancer. There is evidence that exercise can alter p53 levels. This study aimed to investigate the effect of 8 weeks of resistance training on P53 gene expression in prostate cancer patients. Materials and Methods: The statistical population of this randomized clinical trial included men aged 50 to 65 years with prostate cancer. In total, 40 people were selected by convenience sampling and randomly divided into two groups. The first group was subjected to resistance training, and the second group was regarded as a control. The training protocol included a period of resistance training. The obtained data were analyzed in SPSS software (version 20) at a significance level of P≤0.05. Results: Based on the findings, before the intervention, the serum level of P53 was not statistically and significantly different between the two groups (P≤0.05). However, after 8 weeks of intervention, there was a significant difference before and after the intervention in the resistance training group in terms of the value of this variable (P=0.000); however, it showed no significant difference in the control group after 8 weeks (P≤0.05). Conclusion: According to the findings, resistance training increases the serum level of P53 suppressor protein in patients with prostate cancer, and as a result, control and help in the treatment of this cancer.