The effect of renal lymphatic ligation on kidney and blood pressure.

Abstract

This experiment was designed to study the effect of renal lymphatic ligation on renal function and blood flow and to evaluate the sensitivity of the urogram and angiogram as a baromet er of the changes so produced. The effect on systemic blood pressure and an analysis of the probable mechanism for bypass of the obstructed lymphatics are also reported. As a preliminary to this study, male mongrel dogs were subjected to intravenous urography, renal angiography, and three blood pressur e determinations. Five animals which exhibited no abnormality in these paramet ers were employed in the experiment . The lymphatics were visualized by pyelolymphatic backflow. This was produced by the inj ection of a small amount of Sky Blue into the proximal ureter while the ureter was elevated by a probe immediately below the point of injection to temporarily increase the intrapelvic pressure. All the visualized lymphatic trunks were ligated at the renal hilus by clips or fine silk sutures. In some animals, capsular lymphati...