Abstract
An infusion of an isotonic saline solution or of the same solution to which human serum albumin had been added in a concentration of 6 and 25% was administered into the renal artery of rats. The sodium and water excretion and the inulin and PAH clearances were not different when isotonic saline solution or 6% albumin were applied. After an infusion of 25% albumin solution a transient natriuresis and diuresis, accompanied by an increase of blood pressure, was observed. These experiments do not support the hypothesis which suggests the importance of peritubular oncotic pressure for the reabsorption of fluid and sodium in the rat renal tubules.
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