Abstract
Introduction Gap junction mediated electrical coupling is ubiquitous in neuronal systems. Electrical coupling is almost always modeled as a linear ohmic resistance between cells, where the coupling current is proportional to the transjunctional potential. However, many gap junctions exhibit rectification with transjunctional voltage [1]. That is, the coupling conductance attenuates for increased voltage differences between cells. This rectification process can evolve at different time scales. Because gap junction rectification alters the strength of coupling between cells in a way that depends on the intrinsic states of the cells, it may affect the dynamics in neuronal networks. However, the effects of rectification on network dynamics are largely unstudied.
Highlights
Gap junction mediated electrical coupling is ubiquitous in neuronal systems
Our theoretical and computational study shows that rectification of gap junctions can affect neuronal network dynamics in a significant and complex manner
This research supported in part by the NSF Grant DMS-0518022 to TJL
Summary
Gap junction mediated electrical coupling is ubiquitous in neuronal systems. Electrical coupling is almost always modeled as a linear ohmic resistance between cells, where the coupling current is proportional to the transjunctional potential.
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