The effect of quinidine sulfate on QRS duration and QT and systolic time intervals in man.

Abstract

QRS duration, QT interval, total electromechanical systole (QS(2)), left ventricular ejection time (LVET), and preejection period (PEP) were determined in five male and two female healthy volunteers in a fasting state at hourly intervals for 7 hours during a control period and after administration of 400 mg quinidine sulfate. Changes of QRS duration (delta QRS) and rate-corrected QT interval (delta QTc) were calculated before and after quinidine. Deviations of measured QS(2), LVET, and PEP from the normal were calculated as the differences between the observed interval and those predicted from the normal regression equation. The effect of quinidine on systolic time intervals (delta QS(2), delta LVET, DELTA PEP) were expressed as the differences between the deviations from the normal regression equation during the control period and after the drug administration. After quinidine sulfate delta QRS, delta LVET, delta PEP, and delta PEP, delta LVET were slight and inconsistent. However, delta QTc and delta QS(2) were significant (at P is less than 0.05 or better) from the first hour to the 7th hour and from the 2nd hour to the 5th hour, respectively. The mean maximum delta QTc was 44.8 milliseconds and delta QS(2) was 29.9 milliseconds. The significant changes of QTc and QS(2) seemed to occur at the plasma level range of 0.75-1.9 mug/ml. This study indicates that of the various systolic time interval measurements obtained after quinidine administration, the changes of QT interval and QS(2) are most significant and that these changes seem to occur even at low plasma levels.