Abstract
Quercetin, a flavonoid with multiple proven health benefits to both man and animals, displays a plethora of biological activities, collectively referred to as pleiotropic. The most studied of these are antioxidant and anti-inflammatory but modulation of signalling pathways is important as well. One of the lesser-known and recently discovered roles of quercetin, is modulation of microRNA (miRNA) expression. miRNAs are important posttranscriptional modulators that play a critical role in health and disease and many of these non-coding oligonucleotides are recognized as oncogenic or tumor suppressor miRNAs. This review is an evaluation of the recent relevant literature on the subject, with focus on the ability of quercetin to modulate miRNA expression. It includes a summary of recent knowledge on miRNAs deregulated by quercetin, an overview of quercetin pharmacokinetics and miRNA biogenesis, for the interested reader.
Highlights
Quercetin, a biologically active compound, is a member of an extensive group of natural compounds called polyphenols
This study found significant upregulation of miR-146a, approximately four- to five-fold of control for MCF-7/MDA-MB-231 cells, caused by the highest quercetin concentration tested during 48 h treatment
Data presented in this study showed that there is a group of miRNAs which was significantly upregulated (2 miRNAs/4 miRNAs) or downregulated (2 miRNAs /8 miRNAs) in adenocarcinoma/squamous cell carcinoma between groups consuming high and low quantities of quercetin-rich food
Summary
A biologically active compound, is a member of an extensive group of natural compounds called polyphenols. A mouse xenograft model was used during the study These experiments showed decrease in cancer volume and an increase in expression of miR-146a, almost two-fold higher than control, after quercetin treatment (10 mg/kg for 8 weeks). It seems that miR-200b-3p associated activation of Numb is more important than 3’ UTR anti-notch activity If we consider both articles published by Nwaeburu et al.[73,74], we can recognize a synergy in the effect of the two miRNAs, miR-200b-3p and let-7c, on quercetin treated PDA cells. Both miR-200b-3p, and let-7c, upregulate Numb protein, the Notch[1] inhibitor. The authors used miR-143 as a molecule that increases chemosensitivity to quercetin in gastric can-
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