Abstract
Abstract To investigate more accurately the effect of pyrogen from E. coli on liver metabolism, its influence on mitochondrial fractions and on the activity of succinic acid dehydrogenase in this fraction has been studied. It appears that the pyrogen acts by directly activating the enzyme system chosen. Antagonism by malonate confirms the enzymatic and specific character of the phenomenon. No effect of pyrogen was found on the activity of lactic acid dehydrogenase. The results further the conception of a peripheral action of pyrogen.
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