Abstract
The activity of lysyl oxidase, the enzyme responsible for the production of the precursor of the crosslinks of collagen and elastin, was measured in the aortas and epiphyseal cartilage of chicks raised on pyridoxine-deficient and control diets. Lysyl oxidase activity was diminished in both tissues in the deficient chicks, although the activity declined more slowly in the aorta. Deficient chicks given a large dose of pyridoxine 14 hr before sacrifice showed a marked increase in lysyl oxidase levels in both tissues. It is concluded that a pyridoxine derivative as well as copper are essential cofactors for lysyl oxidase.
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