Abstract

In the cytoplasm of central nervous system cells the oxidation of citrate may procede via the NADPdependent isocitrate dehydrogenase (EC 1.1.1.42 (IDH-NADP)) [I]. Atkinson [2] and Chen and Plaut [3] have suggested that the activity of IDH-NAD is regulated by adenine and pyridine nucleotides. Previously we have reported that ATP, according to its concentration, may activate or competitively inhibit IDH-NADP from brain cytosol [6]. Up to now there have been no reports about the effect of pyridine nucleotides on the activity of this enzyme. The present study deals with this problem.

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