The Effect of Puberty on Interaction between Vitamin D Status and Insulin Resistance in Obese Asian-Indian Children

Rajesh Khadgawat,Nandita Gupta,Monita Gahlot,Deepak Khandelwal,Nikhil Tandon,Vin Tangpricha,Tushanth Thomas

doi:10.1155/2012/173581

Rajesh Khadgawat, Nandita Gupta + Show 5 more

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https://doi.org/10.1155/2012/173581

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Abstract

To study the effect of puberty on the relationship between serum 25-hydroxyvitamin D (25(OH)D) and parameters of insulin kinetics in obese Asian-Indian children. Material and Methods. The study population included 62 obese Asian-Indian children and adolescents in the age group of 6–17 years. Blood glucose, serum insulin, and serum 25(OH)D were measured. Total body fat was measured by dual energy X-ray absorptiometry. Indices of insulin resistance (HOMA-IR, AUC for insulin) and sensitivity (WBISI) were calculated after oral glucose tolerance test. Result. A total of 62 subjects (35 boys; mean age = 13.0 ± 3 years; BMI = 29.3 ± 4.8 kg/sq M; 19 subjects in Tanner stage 1, 11 in stage 2, 6 in stage 3, 3 in stage 4, and 23 subjects in Tanner stage 5) were studied. All study subjects were vitamin D deficient with a mean serum 25(OH)D of 8.5 ± 4.2 ng/mL. No significant relationship was observed between serum 25(OH)D and parameters of insulin kinetics in prepubertal children. However, a significant inverse correlation was seen between serum 25(OH)D and HOMAIR (r = −0.41, P = 0.03) in postpubertal subjects. Conclusion. The relationship between vitamin D status and parameters of insulin kinetics are affected by puberty.

Highlights

Vitamin D deficiency was once thought to exclusively affect bone metabolism, but there is ample evidence of its role in many other conditions including metabolic syndrome, autoimmune diseases, and cancer [1]
Versus 3.42 ± 2.7, P < 0.01) and lower insulin resistance (HOMA-Insulin Resistance (IR), mean ± standard deviation (SD) 3.68 ± 2.7 versus 5.22 ± 4.0, P = 0.04) were seen in prepubertal subjects. This is the first study examining the relationship between serum 25(OH)D levels and parameters of insulin resistance in obese Asian-Indian children
We demonstrated trends for that higher serum 25(OH)D levels are associated with better insulin sensitivity and less insulin resistance though this correlation did not reach statistical significance

Summary

Introduction

Vitamin D deficiency was once thought to exclusively affect bone metabolism, but there is ample evidence of its role in many other conditions including metabolic syndrome, autoimmune diseases, and cancer [1]. A systematic review by Pittas and colleagues [3] reported that vitamin D may have a beneficial effect on the action of insulin, either directly or indirectly. Several observational studies in adults, including the Framingham Heart Study [4], have reported an inverse association between vitamin D status and insulin resistance. Data from children and adolescents do not consistently report this inverse relationship [5,6,7,8,9,10]. Even in studies reporting this association in adolescents and children, the strength of association has been found to be very modest [6]. None of the studies in adolescents have studied the effect of puberty on this association. A fall in insulin sensitivity with compensatory increase in insulin secretion has been reported in puberty [11, 12]

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