Abstract
Poor quality protein supports and even potentiates some metabolic responses in DDT + lindane-treated guinea pigs. Ascorbic acid deficiency, on the other hand, impairs induction of most of the responses measured. Animals fed soy protein and gelatin exhibit the highest O-demethylase activity, hepatic glycogen content and urinary excretion of lindane and lindane metabolites. However, only soy protein permitted significant increases in glucaric acid excretion, hepatic cytochrome P-450 content and glucuronyl transferase. Furthermore, only the guinea pigs on soy protein had statistically significant increases in the metabolic stimulation induced by DDT and lindane in the casein-fed animals. Thus, the animals on the soy protein diet excreted significantly more lindane and lindane metabolites as well as more glucaric acid than the guinea pigs receiving casein.
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