Abstract
Since the introduction of intravenous hyperalimentation (IVH) as a nutritional adjunct in multimodal cancer therapy (X), the risk of providing nutrient substrates for more rapid tumor growth has been a concern of those who use IVH to rehabilitate malnourished cancer patients nutritionally. Because of the technical difficulties in studying glucose and amino acid utilization in cancer patients, an experimental model was designed to simulate the nutritional problems encountered in cachectic cancer patients. Tumor-bearing rats were protein depleted with a protein-free diet, and then randomized into three groups which either continued on the protein-free diet, resumed a regular protein diet, or received intravenous hyperalimentation. By manipulating the dietary protein intake, the effects of protein restriction and repletion on host and tumor metabolism could be compared and related to the clinical situation in which hyperalimentation is used to replete malnourished cancer patients nutritionally. Host and tumor metabolism were evaluated by measuring the activity of three important enzymes that control glucose production and specific amino acid degradation. Fructose 1,6-diphosphatase (FDPase, EC 3.1.3.11) is considered one of the rate-limiting enzymes in the gluconeogenic pathway because of its slow kinetics and irreversible catalytic action (25). Glutamate -pyruvate transaminate (GPT, L-alanine:Z
Published Version
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