Abstract
Abstract 1.1. Protamine sulfate markedly inhibits the formation of plasma thromboplastic activity as measured in the thromboplastin generation test of Biggs and Douglas. 2.2. Protamine has less effect on "formed thromboplastin" after the point of optimum generation. 3.3. The inhibition of thromboplastin generation by protamine appears to be due to interference with PTC activity. 4.4. The inhibition of thromboplastic activity by protamine can be counteracted by heparin. 5.5. Twice as much heparin is required to neutralize the protamine effect before generation is started than is required to correct thromboplastic activity after generation is begun in the presence of protamine.
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