Abstract
Prostaglandin F2u (PGF20) may provoke luteolysis in guinea pigs indirectly by causing changes in ovarian blood flow. To testthishypothesis, 15 �m and 25Mm radiolabeledmicrospheres were injected into guinea pigs before and after treatment with saline or a dose of PGF,a which resulted in a significant decrease in plasma progesterone concentrations. The percent cardiac output to the ovaries and the percent arteriole-venule shunting within the ovaries estimated by the number of microspheres in this tissue were unchanged 6 h after treatment, yet plasma progesterone concentratiOns were significantly reduced in the PGF,a treated animals. These results, although confirming the luteolytic action of PGF,0 in guinea pigs, suggest that its mode of action does not require the intervention of hemodynamic adjustments.
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