Abstract
The rise in arterial blood pressure in response to angiotensin II was studied in the last third of pregnancy in rabbits. The response was compared with that of pregnant rabbits during infusion of prostaglandin E 2 and F 2α. Prostaglandin E 2 significantly diminished the rise in diastolic pressure in response to angiotensin II. Prostaglandin F 2α did not alter the response. Intravenous indomethacin elevated the blood pressure and caused an absolute increase in the pressor response. It did not mediate a change in the percentage rise in blood pressure in response to angiotensin II.
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