Abstract
Obesity causes chronic inflammatory reaction is characterized by elevated levels of high sensitivity c-reactive protein (hscrp). Hscrp and hdl could be used as an early marker of cardiovascular disease risk. Tempeh gembus contain fiber, unsaturated fatty acids and antioxidants, which can reduce the inflammatory reaction. This study determines the effect of processed Tempeh gembus on hsCRP and HDL in obese women. This study included in experimental studies with randomized post-test only control group design involving 40 obese women aged 20 – 50 years. Subjects were randomized into two groups: a control group was given a standard diet low in calories 30 calories/kg body weight, and the treatment group was given a standard diet low in calories 30 calories/kg body weight and Tempeh gembus for 28 days. hsCRP and HDL levels were measured before and after the intervention, food intake was measured by using a 3 x 24-hour recall and physical activity (IPAQ form). HsCRP levels were measured using the ELISA method, whereas HDL levels were measured using the CHOD-PAP method. Wilcoxon test (hsCRP levels) and paired t-test (HDL levels) used to test differeces before and after intervention each group. Mann Whitney test (hsCRP levels) and independent sample test (HDL levels) used to test differeces before and after intervention between groups. There are differences in hsCRP levels before and after the intervention in the control group (p = 0.00) and the treatment group (p = 0.00). There are differences in HDL levels before and after the intervention in the control group (p = 0.00) and the treatment group (p = 0.00). There are differences in the decrease hsCRP levels between the two groups (p = 0.00). There are differences in the increase in HDL levels between the two groups (p = 0.03). Tempeh gembus 150 grams/day can decrease hsCRP levels and increase HDL levels in women with obesity.
Highlights
Obesity is excessive fat accumulation due to an imbalance between energy intake and energy released by the body so that it can interfere with health (WHO, 2016)
Subjects were randomized into two groups: a control group was given a standard diet low in calories 30 calories/kg body weight, and the treatment group was given a standard diet low in calories 30 calories/kg body weight and Tempeh gembus for 28 days. high sensitivity C-reactive protein (hsCRP) and high density lipoprotein (HDL) levels were measured before and after the intervention, food intake was measured by using a 3 x 24-hour recall and physical activity (IPAQ form)
Excessive adipose tissue causing chronic inflammatory reactions due to cytokine secretion and proinflamator by adipocyte cells are characterized by increased levels of high sensitivity C-reactive protein, Tumor Necrosis Factor (TNFα), interferon-gamma (IFN γ) and interleukin-6 (IL-6) (Guillen et al, 2008; Libby, Ridker and Maseri, 2002). hsCRP is a biomarker that is sensitive to the occurrence of inflammation in the body and is a strong predictor of the incidence of cardiovascular system disease (Tully et al, 2015)
Summary
Obesity is excessive fat accumulation due to an imbalance between energy intake and energy released by the body so that it can interfere with health (WHO, 2016). The mean protein intake before the study in the control group (84.86 ±19.08 grams) was higher than the treatment group (72.59 ±19.16 grams), the independent sample test showed that there were significant differences in energy intake between groups (p = 0.04) so that protein intake before it can become confounding variables.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
