The Effect of Premedication with Ketorolac on Pain Relief During Chemical Peeling

Abstract

Background: A majority of patients undergoing chemical peeling complain of pain severe enough to disturb the process of the peeling. However, there has been few controlled studies on pain control during chemical peeling. Objectives: We evaluated the efficacy and safety of pretreatment with intramuscular ketorolac (Tarasyn, 30mg)and oral diazepam(Valium, 5mg)in comparison with control and diazepam groups, and compared the sensitivity of pain between two sexes. Methods: The patients were randomly assigned to one of three groups;control, diazepam, and ketorolac plus diazepam groups. Pain intensity was assessed 5 times at every ten minutes from the beginning of the peeling using visual analog scale(VAS). Results: At every 10 minutes of pain assessment, ketorolac plus diazepam group recorded the lowest VAS among the three groups. Except at the first 10 minutes, nificant. There was no significant difference in the pain intensity between the sexes at all five times. After application of Jessner`s solution, there was significant increase of VAS in all groups. Conclusion: The ketorolac pretreatment is a safe and effective modality of pain relief prior to chemical peeling without the adverse reactions. (Ann Dermatol 14(1)18-21,2002).