Abstract
The effect of preinspiratory lung volume on the slope of the nitrogen plateau after a single breath of 750 ml of oxygen has been studied in a group of normal subjects. The slope of the plateau expressed as the nitrogen concentration difference between points 750 ml and 1250 ml after the beginning of expiration is found to be a function of preinspiratory lung volume. There is a linear relationship between nitrogen difference and the preinspiratory volume above R.V. Change in shape of the plateau with diminishing lung volume appeared to be related to the age of the subjects. The significance of the results is discussed.
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