Abstract
Marked interlaboratory variation exists in the analysis of various clinical chemistry parameters, particularly in lactate dehydrogenase (LDH) and creatine kinase (CK) activity in the rat. Much of this variation is due to the handling of the animal prior to sampling, the method and site of sampling, and the handling of the sample prior to analysis. Such preanalytical conditions can lead to spurious high values, which in turn may lead to misinterpretation of test article effects in toxicological studies. This paper reviews the literature with respect to preanalytical conditions and their effect on LDH and CK, and reports on our own investigations, in the hope of increasing the awareness among investigators of these problems, leading to the elimination of inappropriate sampling and handling techniques.
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