The Effect of Pre-irradiation Chemotherapy on Event-free and Overall Survival in Pediatric Low-grade Glioma

Abstract

Purpose/Objective(s):Chemotherapy is considered the treatment of choice for inoperable intracranial low-gradeglioma (LGG) in young children. Children under the age of 5 years who receive radiation therapy (RT) risk significant cognitive effects and vasculopathy. Although older patients have fewer complicationswithRT, somewould consider the use of chemotherapy to be appropriate regardless of age. We sought to determine if chemotherapy administered prior to RT reduced progression-free or overall survival.