Abstract
Objective: To explore the role of PPARγ activation on fracture healing in rabbits and combination optimization. Methods: 18 rabbit can be divided into 3 groups, control group, PPARγ activation group, optimization group. Then 3 groups are copied rabbit fracture model, after the success, PPARγ activation group taking rosiglitazone (0.5 mg/kg), optimization group taking rosiglitazone (0.5 mg/kg)+ rosuvastatin (1.0 mg/kg); the control group taking suit amount of dilution solvent, once a day. Test FPG, TG, BMP-2, TGF-β1, PDGF, bFGF level and pat X-ray compare to each other after 5 weeks. Results: PPARγ activation can reduce rabbit BMP-2, TGF-β1, PDGF, bFGF levels (P < 0.01 or P < 0.05), rosuvastatin can reverse PPARγ activation cause BMP-2, TGF-β1, PDGF, bFGF levels lower (P < 0.01 or P < 0.05), and can not affec the FPG level (P > 0.05). X-ray showed that poor fracture healing of PPARγ activation group and better fracture healing of optimization group. Conclusion: PPARγ activation group fracture healing showed low BMP-2, TGF-β <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> , PDGF, bFGF levels, but rosuvastatin can reverse the situation, and will not affect the FPG level.
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