The effect of postinjury administration of polyethylene glycol-conjugated superoxide dismutase (pegorgotein, Dismutec) or lidocaine on behavioral function following fluid-percussion brain injury in rats.

Abstract

Previous studies in our laboratory have shown that polyethylene glycol-conjugated superoxide dismutase (PEG-SOD) or lidocaine treatment before experimental fluid-percussion brain injury in rats reduces the cortical hypoperfusion normally found in the early posttraumatic period. The purpose of the current study was to determine if posttreatment with PEG-SOD or lidocaine is also associated with changes in the trauma-induced suppression of motor and cognitive function that occurs following traumatic brain injury (TBI). Twenty-four hours after surgical preparation, rats were randomly assigned to a saline or drug posttreatment group, PEG-SOD (pegorgotein, Dismutec 10,000 IU/kg) or lidocaine (2 mg/kg), which was injected iv 30 min after moderate injury. PEG-SOD completely prevented beam walk deficits on days 1-5 postinjury while lidocaine similarly prevented beam walk deficits on days 2 through 5 postinjury. Both drugs produced a statistically insignificant trend for a decrease in beam balance duration deficits on days 1-5 postinjury and had no effect on cognitive function, as assessed by the Morris water maze, on days 11 through 15 postinjury. The mechanism by which PEG-SOD and lidocaine reduce posttraumatic motor deficits may be related to their free radical scavenging effect or previously reported effects on posttraumatic cerebral blood flow. To our knowledge, this is the first report of the effectiveness of these two agents in laboratory animals when administered after traumatic injury.