The Effect of Pomegranate Peel Extract on Collagen Total, Interleukin-6 and Vascular Endothelial Growth Factor Receptor (VEGF) Levels

Abstract

Treatment and rehabilitation of burns requires perseverance, high costs, trained and skilled personnel, therefore a breakthrough is needed to address this problem in an effective, safe and affordable way. One of the breakthrough alternatives is to use natural ingredients such as pomegranate peels. The purpose of this study was to determine the effect of giving pomegranate peel extract orally on levels of IL-6, VEGF and the amount of collagen of male Sprague Dawley rats that were given second degree burns. The design of this study was experimental with a post-test only control group design approach. The subjects of the study were 24 male Sprague Dawley rats which were randomly divided into 4 groups. Group K, P1, P2, and P3. Groups P1, P2, and P3 were given second degree burns and given pomegranate peel extract at doses of 54, 108, 162 mg/200 g BW. On the 3rd day an IL-6 examination was carried out at PSPG UGM and on the 7th day a termination was carried out and an examination was carried out for VEGF and the amount of collagen at the SSCR FK UNISSULA in January 2022. The One Way Anova test showed levels of IL-6, VEGF and the amount of collagen in between groups, there is a significant difference with each value of p=0.000, p=0.029 and p=0.000 (p<0.05). Administration of pomegranate peel extract at doses of 54, 108, 162 mg/200 g BW can reduce IL-6 levels, increase VEGF, and increase the amount of collagen of male Sprague Dawley rats that were given second degree burns.