Abstract
Objective: To determine the effect of polymorphism of estrogen receptor β to the risk of epithelial ovarian carcinoma at Dr. Mohammad Hoesin Hospital Palembang
 Methods: This population-based case control study included 40 women with epithelial ovarian carcinoma and 40 controls, from January 2010 until December 2011. Data analysis was performed by Chi Square test.
 
 Results: Distribution of estrogen receptor beta genotypes, both GT and TT (wild type-mutant and mutant), among case subjects was significantly higher than control (24 subjects {60%} vs. 5 subjects {12.5%}). The genotype effect was statistically significant for rs1271572 (OR=2.636; p=0.039) with Chi Square analysis. Whereas
 the allotype effect was also statistically significant (OR=1.949; p= 0.047).
 
 Conclusion: Polymorphism of estrogen receptor β may play a role in the risk of epithelial ovarian carcinoma at Dr. Mohammad Hoesin Hospital Palembang.
 [Indones J Obstet Gynecol 2012; 36-1:32-6]
 
 Keywords: epithelial ovarian carcinoma, polymorphism of estrogen receptor β, risk factor of ovarian carcinoma
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