The Effect of Polymorphism A/T 251 of the IL-8 Gene on Breast Cancer: A Systematic Review and Meta-Analysis

Abstract

PurposeBreast cancer is the most common cancer in women. In recent research works, the role of cytokines in development of cancer has attracted attention. Therefore, this paper intends to comprehensively assess the association between breast cancer and polymorphism A/T 251 from the IL-8 gene using meta-analysis.MethodsIn this study, to find articles published electronically between 2004 and 2020, national and international databases of SID, MagIran, Embase, ScienceDirect, Scopus, PubMed, and Web of Science (WoS).ResultsThe odds ratio of AA genotype in patients with breast cancer based was obtained as 1.42 (1.11–1.82: 95% confidence interval), which shows the increasing effect of AA genotype by 0.42, the odds ratio of the AT genotype in patients with breast cancer based on a meta-analysis of studies was obtained as 1.01 (0.84–1.22: 95% confidence interval), which demonstrates the increasing effect of the AT genotype by 0.01, and the odds ratio of the TT genotype in patients with breast cancer was similarly obtained and was 0.95 (1.08–0.24: 95% confidence limit), which shows the decreasing effect of TT genotype by 0.05.ConclusionAccording to this meta-analysis, allele A has a significant relationship with breast cancer, which can be used as a predictor of the course of the disease and the clinical outcome of breast cancer. Identifying polymorphism A/T 251 from the IL-8 gene, as a genetic marker and predictor, can also be effective in treating breast cancer.