Abstract
In this study, pH-sensitive blended polymeric beads were prepared by ionic gelation of mixed alginate and N,O-carboxymethyl chitosan (NOCC) solutions in aqueous media containing calcium chloride. To prepare drug-loaded beads, sulfasalazine (SA) as a model drug was added to the initial aqueous polymer solution. These beads were characterized and evaluated in vitro as potential carriers for colon-specific drug delivery. A 32 full factorial experimental design was employed to evaluate the effect of polymer and CaCl2 concentrations on swelling and drug release behavior of the beads in simulated gastrointestinal tract fluid. It was found that the rate of swelling and drug release decreased significantly with increasing polymer and CaCl2 concentrations, but polymer concentration was more effective than CaCl2 concentration. The beads prepared using 4.5% polymer concentration and 4% CaCl2 concentration retained approximately 60% of the loaded drug before approaching the simulated colonic fluid. Based on the results, the alginate-NOCC beads prepared with high polymer concentration could be potentially suitable polymeric carriers for colon-specific delivery of SA.Electronic supplementary materialThe online version of this article (doi:10.1186/2194-0517-2-10) contains supplementary material, which is available to authorized users.
Highlights
The wound is a rupture in the epithelial integrity of the skinbased structural changes and functions of tissues
The medicinal plants have been borne witnessed as the paramount source of various phytochemicals used for the biogenic synthesis
The brown mass fraction was subjected to LCMS-8030 for characterization of the flavonoid compounds
Summary
The wound is a rupture in the epithelial integrity of the skinbased structural changes and functions of tissues. Impaired wound healing results in severe morbidity leading to long hospitalization of patients. There is always demand for treating wounds for minimization of the time taken for healing and to step down the risks of undesired complications (Ahmadi and Adibhesami 2017; Kandhasamy et al 2017). The use of conventional synthetic drugs over a long time is affiliated with side effects such as coma, hallucinations, kidney, heart, and liver failure (Biondi-Zoccai et al 2006). The use of plant-based nanomaterials has been accounted as a practical approach with improved physico-biochemical properties and functionality (Khoobchandani et al 2013; Katti 2016). The biogenic nanoparticles have shown promising potential as wound healing agents. The green nanotechnology is an open inquisitive field of research for the enhancement of bio-efficacy and has been exploited in the development of nanodrugs (Murugan et al 2015; Singh et al 2018)
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