Abstract
It is shown that: (1) The isolated stratum corneum has a very low electrical resistance. 1. (2) The passive sodium flux through the isolated s. corneum is 20–100 times higher than the active sodium transport. 2. (3) Polyene antibiotics (amphotericin B and filimarisin) abolish the aldosterone induced inhibition of the active sodium transport. 3. (4) Aldosterone induces a recovery in the electrical potential across skins where it had been reduced previously by the addition of a polyene antibiotic. 4. (5) An hypothesis is presented to explain these observations.
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