Abstract
Leukocytes and platelets are known to adhere to a variety of materials [1]. Already in 1928, Fleming used cotton wool to remove leukocytes from small amounts of blood [2]. This was the basis for the preparation of leukocyte-poor red cell concentrates (RBC) for transfusion many years later [3,4]. In 1972 Diepenhorst et al. [3] described the first leukocyte depletion filter which was composed of a column filled with tightly packed cotton wool fibers, providing a network with equally distributed pores. The retention of both granulocytes and lymphocytes in this cotton-wool filter was independent of Ca2+ and Mg2+ and hematocrit and slightly temperature dependent.
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