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Abstract
Objectives:To analyze the immediate effect of platelet rich plasma, combined with celecoxib, on knee function and pain in patients with knee osteoarthritis.Methods:The clinical data of 86 patients with knee osteoarthritis, treated in our hospital from January 2019 to January 2021, were analyzed retrospectively. According to the treatment records, patients were divided into a control group (n = 43, celecoxib) and a treatment group (n = 43, platelet rich plasma + celecoxib). The knee function, pain and clinical effect in the two groups were compared and analyzed using the Hospital for Special Surgery (HSS) knee score and the visual analog scale (VAS).Results:The treatment group had a higher HSS score, and a lower VAS score compared to the control group (P<0.05). The clinical efficacy in the treatment group was higher than that in the control group (95.35% and 72.09% respectively, P<0.05).Conclusions:Platelet rich plasma combined with celecoxib can promote the recovery of knee function and reduce pain in patients with knee osteoarthritis. This treatment combination also has a high immediate clinical effectiveness but needs further evaluation to find out the long term effects.
Highlights
Knee osteoarthritis is a progressive degeneration of the articular cartilage of the synovial joint which changes the joint edge and cartilage tissue
A total of 86 patients with knee osteoarthritis were included in this study, 43 in the control group and 43 in the treatment group
This study found that the Hospital for Special Surgery (HSS) and visual analog scale (VAS) scores of the treatment group that received a combination of platelet rich plasma and celecoxib, were significantly better than those of the control group (P
Summary
Knee osteoarthritis is a progressive degeneration of the articular cartilage of the synovial joint which changes the joint edge and cartilage tissue. This leads to hyperplasia of the articular capsule fiber, joint pain, and joint function loss, and severely reduces the quality of daily life of patients.[1,2]. There is a focus on symptomatic support and drug treatment for knee osteoarthritis. Celecoxib is a common therapeutic drug for patients with knee osteoarthritis, which can reduce pain and improve knee function, but may cause adverse reactions, such as nausea, vomiting and dizziness, which limits the scope of its application. Platelet rich plasma in combination with celecoxib is a new treatment for knee osteoarthritis.
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