Abstract
The diuretic action of pituitary extract described first by Magnus and Schafer1 has since been observed by many. More recently an anti-diuretic action of this extract has been observed, especially in connection with diabetes insipidus, and in relation to water intoxication. (For literature see Weir, Larson and Rowntree.2) On account of its diuretic action one might expect some effect on the composition of the blood. Underhill and Pack3 and Mackersie4 observed a dilution of the blood after pituitrin injection, but only a few experiments were made. Rowntree,2 however, observed no change in blood volume, and Lamson,5 who injected physiological salt along with pituitrin observed no change with small doses, but found that after large doses of pituitrin, the physiological salt did not leave the blood as it normally does, but kept the blood diluted for hours.We have followed the concentration of the blood in 20 dogs after pituitrin injection, using 2 or 3 cc. of Parke Davis's obstetrical pituitrin. In 16 of thes...
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